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Detoxamin is an easy,
low-toxicity, simple way to absorb EDTA. For years, many chelation
physicians have argued that intravenous EDTA introduces too much EDTA
too soon. However, when taken rectally with Detoxamin, EDTA metabolizes
much slower. The
result of this is that the EDTA through Detoxamin is able to chelate
more toxic metals, while putting much less burden on the liver and
kidney. It is evident that the slower the infusion of EDTA, the greater
possibility for the EDTA to chelate the toxic metals. Additionally,
during sleep the blood flow to the brain increases, once again giving
an optimal chance to chelate from the brain. Detoxamin Combines Three Great Features: - Low dose (toxicity) but provided more frequently.
- Low tech and cost (no nurses, no I.V. drip material, and minimal clinic time).
- Patients are getting the benefits for lying in a supine position and asleep.
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EDTA,
like many other pharmaceuticals and nutraceuticals, are readily
absorbed in the rectum and descending colon (see study; Proof of EDTA's
Permeability by Way of the Colon, by Ella R, Behrens, C Northrup, P
Wraight and G. Neale, Dunn Clinical Nutrition Centre and New
Addenbrooke's Hospital, Cambridge, UK.- ) In fact, we are taking
advantage of nature since the descending colon and sigmoid colon is
where the body reabsorbs water from fecal material. In a healthy colon,
in the presence of whole grains the Candida will produce several
B-complex vitamins. Detoxamin does not irritate the rectal mucosa.
Carpological examinations have proven that Detoxamin patients did not
present with mucus or more mucosa material than normal. The cocoa
butter base helps keep any irritation down. In fact, most people feel
their bowel movements are easier when on Detoxamin.
November, 6 2002 RE: Rectal Mucosa To whom it may concern: The overwhelming clinical experiences with using various forms of EDTA suppositories supports the conclusion;
a.
Using the Calcium Di-sodium EDTA, if properly administered and
providing you use less than 1000 mgs per suppository, combined with
cocoa-butter provides an entirely safe mode of administration.
b.
The Calcium Di-sodium EDTA suppository is comfortable to use as the
calcium is able to buffer and potential caustic or stinging that the
EDTA salt-like crystals might otherwise cause. |
Conclusion.
Detoxamin is the only chelation suppository product on the market that
has all of the following attributes: legal, safe, comfortable to use
and has documented proof of its consistent effectiveness in its ability
to chelate. Dr. Bruce Halstead
"The Father of Medical Chelation Therapy"
Scientific Advisor,
World Health Products, Inc.
The Proof of It's Permeability and Why it's a viable Alternative to IV EDTA Chelation. There
have been many that have questioned the absorption ability of the
Ca-EDTA contained in Detoxamin. This question is understood, as rectal
suppositories are relatively new. In other words, the understanding of
rectal absorption is not well known or understood. The following data
should prove to the reader that the Ca-EDTA contained in Detoxamin is
well absorbed and well tolerated by the colon. Detoxamin is producing
results comparable to that of the intravenous method of EDTA chelation
and the following information should help explain why Detoxamin is a
viable alternative to IV EDTA chelation. According to the AMERICAN ACADEMY OF PEDIATRICS, Alternative Routes of Drug Administration-Advantages and Disadvantages (Subject Review) (RE9723):
A. Rectal administration provides rapid absorption of many drugs and may be an easy alternative to the intravenous route.
B. Uptake may be almost as rapid as if an intravenous bolus were administered. |
Note:
Some IV chelation doctors are now introducing what they call a "rapid
5-minute IV push" which introduces 3 grams of EDTA in 5 minutes. This
is the same as a "bolus" effect. According to the AMERICAN ACADEMY OF PEDIATRICS: The rate of rectal transmucosal absorption is affected by the following factors: - Formulation (time to liquefaction of suppositories).
Detoxamin is made up in a cocoa-butter base with methocel E4M (fatty
acid base) which acts as a time-release agent and releases the EDTA
slowly, over an 80-minute period. This ensures a slow release of EDTA
through the colon wall. Because EDTA is readily and well absorbed by
the colon, we slow down the absorption to accomplish a slower release
of EDTA, therefore achieving better results and safer administration.
- Presence of stool in the rectal vault. This variable is eliminated by following the proper usage instructions.
- Rectal retention of the drug administered.
The study "Evaluation of mannitol, lactulose and Cr-labeled
ethylenediaminetetra-acetate as markers of intestinal permeability in
man", M. Elia, R. Behrens, C. Northrup, P. Wraight, G. Neale: Dun
Clinical Nutrition Centre and New Addenbrooke's Hospital, Cambridge,
U.K. on paragraph 8 of the summary conclude:
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"The
data suggests that the uptake of lactulose by the small intestine
persists for longer than the uptake of mannitol, and show that CR-EDTA is readily absorbed in the colon". The
EDTA in Detoxamin is highly absorbed. The convenience factor and the
less invasive use make Detoxamin a viable option for people who cannot
or are unwilling to undergo the IV method. The high absorption (90-95%) makes Detoxamin a feasible alternative to IV EDTA Chelation. There are a few reasons for this: - Detoxamin
introduces less dosage of EDTA, but more frequently. IV chelation
introduces on average 2 grams of EDTA per treatment. Detoxamin
introduces 750 mg of EDTA, but is does it more often. Each 3 Detoxamin
Suppositories will introduce the same amount of EDTA that you receive
in 1 IV treatment. The more consistent and lower dosage uses the EDTA
more efficiently.
- Detoxamin is taken at night, prior to
bedtime. This allows for less metabolic competition for the EDTA,
therefore the EDTA in Detoxamin is more productive because it does have
to work as hard.
- The body at night is in a supine position (flat), therefore the EDTA has less resistance to chelating the entire body.
- Much
safer. When EDTA is taken rectally, it travels through the body much
slower than that of the IV method, not putting the same burden on the
liver and kidneys. Plus, Detoxamin introduces less dosage of EDTA; this
combined with the slower delivery of EDTA makes Detoxamin much safer
compared to the IV method.
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The Safety of the Mucosal Lining Dr.
Bruce Halstead MD, was the original scientific advisor the developing
the EDTA suppository for World Health Products, he has this to say: "The overwhelming clinical experiences with using various forms of EDTA suppositories supports the conclusion; | a.
Using the Calcium Di-sodium EDTA, if properly administered and
providing you use less than 1000 mgs per suppository, combined with
cocoa butter provides and entirely safe mode of administration. b.
The Calcium-Di-sodium EDTA suppository is comfortable to use as the
calcium is able to buffer and potential caustic or stinging that the
EDTA salt-like crystals might otherwise cause." |
Suppositories
are a very feasible route of administration for medication. The
presumed vanity of North Americans has seemingly deterred healthcare
professionals in the United States and Canada from using suppositories
more frequently as a means of delivering medications. In contrast, most
Europeans have no qualms about using suppositories. It is well
recognized that the over-the-counter therapy with suppositories is an
enormously large market. Healthcare professionals and consumers alike
will find that Detoxamin makes EDTA chelation much more simplified and
safer. The fact that the suppository market is growing indicates that
North Americans are willing to utilize suppositories. Within
the era of cost-containment and the risk of AIDS and other communicable
blood-borne diseases, suppository delivery is becoming a more viable
option. Suppositories provide direct access to the systemic
circulation, efficiently bypassing the portal circulation and the liver
on the first pass. It is a little known fact that the lower and the
middle hemorrhoidal veins bypass the liver and do not undergo first
pass metabolism. Therefore, suppositories can deliver the drug more
rapidly to the lower and middle hemorrhoidal veins for absorption. The
rectum is an interesting area for drug absorption because it is not
buffered and has a neutral pH. It also has very little enzymatic
activity, thus enzymatic degradation does not occur. Our Clinical Study Detoxamin
underwent a clinical study in 1998, in the Dominican Republic and it
focused on lead poisoned children. Ted Rozema MD was the research
physician, past president of ACAM. These children had elevated blood
lead levels that were caused by their environment that caused the lead
poisoning. Our clinical study test results clearly demonstrates the
high level of effectiveness of removing lead from the human body with
Ca-EDTA. The FDA approved EDTA chelation for the removal of lead from
the human body, we therefore wanted to prove Detoxamin eliminated lead just
as effective as the IV method did. In other words, we proved
Detoxamin's absorption ability into the bloodstream by measuring
urinary lead excretion levels. It
was proven that after the 1st suppository urine lead excretion levels
went from pre study of; 4.23 mcd/gl to ; 325.55 mcd/gl. These
results make it easy to conclude that Detoxamin EDTA Suppositories are
absorbed very highly into the bloodstream, otherwise we could not have
achieved these unbelievable results with urinary lead excretion.
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Health Notes
Detoxamin - Chelation
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